A PD-1/PD-L1 interaction inhibitor
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CAY10774

Item No. 32569

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-1-[[3-bromo-4-[(2-bromo[1,1′-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
CAS Number
2714327-65-6
Molecular Formula
C26H25Br2NO3
Formula Weight
559.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
SMILES
BrC1=C(COC2=CC=C(CN3CCCC[C@H]3C(O)=O)C=C2Br)C=CC=C1C4=CC=CC=C4
InChi Code
InChI=1S/C26H25Br2NO3/c27-22-15-18(16-29-14-5-4-11-23(29)26(30)31)12-13-24(22)32-17-20-9-6-10-21(25(20)28)19-7-2-1-3-8-19/h1-3,6-10,12-13,15,23H,4-5,11,14,16-17H2,(H,30,31)/t23-/m0/s1
InChi Key
AHFXYBDSOWECNI-QHCPKHFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $68

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    5 mg

    $268

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    10 mg

    $469

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    Product Description

    CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50 = 15 nM in a homologous time-resolved fret (HTRF) assay).1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50 = 6.6 µM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+ and CD8+ T cells co-cultured with aAPCs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Konieczny, M., Musielak, B., Kocik, J., et al. Di-bromo-based small-molecule inhibitors of the PD-1/PD-L1 immune checkpoint. J. Med. Chem. 63(19), 11271-11285 (2020).