A SARS-CoV entry inhibitor
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SSAA09E1

Item No. 32582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2Z)-2-[1-(2-thienyl)ethylidene]-hydrazinecarbothioamide
CAS Number
433212-75-0
Molecular Formula
C7H9N3S2
Formula Weight
199.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: soluble
λmax
257, 327 nm
SMILES
NC(N/N=C(C1=CC=CS1)/C)=S
InChi Code
InChI=1S/C7H9N3S2/c1-5(9-10-7(8)11)6-3-2-4-12-6/h2-4H,1H3,(H3,8,10,11)/b9-5-
InChi Key
PJVHAJJEMJNPHN-UITAMQMPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $161

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    10 mg

    $303

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    25 mg

    $653

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    Cayman Chemical
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    Product Description

    SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1 It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV spike glycoprotein (EC50 = 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50 = 5.33 µM) but not cathepsin B when used at a concentration of 20 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adedeji, A.O., Severson, W., Jonsson, C., et al. Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms. J. Virol. 87(14), 8017-8028 (2013).