A gut-restrictive antibiotic
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HSGN-218

Item No. 32711

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl]-4-[(trifluoromethyl)thio]-benzamide
CAS Number
2519410-44-5
Molecular Formula
C16H8Cl2F3N3O2S
Formula Weight
434.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 1 mg/ml
λmax
281 nm
SMILES
ClC1=CC(Cl)=CC(C2=NN=C(NC(C3=CC=C(SC(F)(F)F)C=C3)=O)O2)=C1
InChi Code
InChI=1S/C16H8Cl2F3N3O2S/c17-10-5-9(6-11(18)7-10)14-23-24-15(26-14)22-13(25)8-1-3-12(4-2-8)27-16(19,20)21/h1-7H,(H,22,24,25)
InChi Key
YNSLXRYEPGHGRY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    HSGN-218 is a gut-restrictive antibiotic.1 It is active against C. difficile (MIC = 0.007 µg/ml) and clinical isolates of C. difficile (MICs = 0.003-0.03 µg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 µg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice from C. difficile recurrence in mouse models of C. difficile infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Naclerio, G.A., Abutaleb, N.S., Li, D., et al. Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivo. J. Med. Chem. 63(20), 11934-11944 (2020).