An inhibitor of UGT8
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

UGT8 Inhibitor 19

Item No. 32723

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-methyl-2-(trifluoromethoxy)ethyl]-carbamic acid, 1-[3-[(methylamino)carbonyl]-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl]-4-piperidinyl ester
CAS Number
2414349-93-0
Synonyms
  • Ceramide Galactosyltransferase Inhibitor 19
  • CGT Inhibitor 19
  • UDP-galactose Ceramide Galactosyltransferase Inhibitor 19
Molecular Formula
C20H22F6N4O4S
Formula Weight
528.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 25 mg/ml
λmax
218, 252 nm
SMILES
CNC(C(C1=NC(N2CCC(CC2)OC(N[C@@H](C)COC(F)(F)F)=O)=C3)=CSC1=C3C(F)(F)F)=O
InChi Code
InChI=1S/C20H22F6N4O4S/c1-10(8-33-20(24,25)26)28-18(32)34-11-3-5-30(6-4-11)14-7-13(19(21,22)23)16-15(29-14)12(9-35-16)17(31)27-2/h7,9-11H,3-6,8H2,1-2H3,(H,27,31)(H,28,32)/t10-/m0/s1
InChi Key
UQQUABVWYAPTIQ-JTQLQIEISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $54

    Add

    5 mg

    $250

    Add

    10 mg

    $470

    Add

    25 mg

    $976

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    UGT8 inhibitor 19 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50 = 0.2 nM).1 It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all). In vivo, UGT8 inhibitor 19 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thurairatnam, S., Lim, S., Barker, R.H., Jr., et al. Brain penetrable inhibitors of ceramide galactosyltransferase for the treatment of lysosomal storage disorders. ACS Med. Chem. Lett. 11(10), 2010-2016 (2020).