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There are two classes of estrogen receptors (ER,) the first is intracellular and translocate to the nucleus when activated through binding to 17β estradiol. They are named ERα and ERβ. The second G protein couples receptors which are membranes proteins and have intracellular signaling function. Central ERα signaling is necessary for the actions of GLP-1 on food-reward behavior. [Bertin Catalog No. G01011]
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