A dopamine D1 receptor partial agonist
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N-Allyl-(±)-SKF 38393 (hydrobromide)

Item No. 32776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol, monohydrobromide
CAS Number
300561-58-4
Molecular Formula
C19H21NO2 • HBr
Formula Weight
376.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 10 mMWater: 10 mM
SMILES
OC1=C(O)C=C(C(CN(CC2)CC=C)C3=CC=CC=C3)C2=C1.Br
InChi Code
InChI=1S/C19H21NO2.BrH/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14;/h2-7,11-12,17,21-22H,1,8-10,13H2;1H
InChi Key
JWQRAXTWDYUBFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $80

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    10 mg

    $119

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    25 mg

    $274

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    Product Description

    N-Allyl-(±)-SKF 38393 is a dopamine D1 receptor partial agonist.1 It is selective for dopamine D1 over D2 receptors in radioligand binding assays (Kis = 302 and 5,250 nM, respectively). N-Allyl-(±)-SKF 38393 reduces food intake in rats (ED50 = 3.6 mg/kg).2 It reduces cocaine and food self-administration in squirrel monkeys when administered at doses ranging from 0.1 to 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daly, S.A., and Waddington, J.L. D-1 dopamine receptors and the topography of unconditioned motor behaviour: studies with the selective, 'full efficacy’ benzazepine D-1 agonist SKF 83189. J. Psychopharmacol. 6(1), 50-60 (1992).

    2. Terry, P., and Katz, J.L. Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the rat. Psychopharmacology (Berl) 109(4), 403-409 (1992).

    3. Platt, D.M., Rowlett, J.K., and Spealman, R.D. Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys. Psychopharmacology (Berl) 157(2), 208-216 (2001).