A PDI inhibitor
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PACMA 31

Item No. 32812

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine, ethyl ester
CAS Number
1401089-31-3
Molecular Formula
C21H22N2O6S
Formula Weight
430.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
O=C(N(C(C1=CC=CS1)C(NCC(OCC)=O)=O)C2=CC=C(C=C2OC)OC)C#C
InChi Code
InChI=1S/C21H22N2O6S/c1-5-18(24)23(15-10-9-14(27-3)12-16(15)28-4)20(17-8-7-11-30-17)21(26)22-13-19(25)29-6-2/h1,7-12,20H,6,13H2,2-4H3,(H,22,26)
InChi Key
AHOOZADJPNUFOQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $115

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    25 mg

    $233

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    Cayman Chemical
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    Product Description

    PACMA 31 is an irreversible inhibitor of protein disulfide isomerase (PDI; IC50 = 10 µM), an endoplasmic reticulum chaperone protein that catalyzes disulfide bond breakage, formation, and rearrangement.1 It inhibits PDI chaperone activity in a concentration- and time-dependent manner in an insulin aggregation assay and is cytotoxic to OVCAR-8 and OVCAR-3 ovarian cancer cells (IC50s = 0.9 and 0.32 µM, respectively). PACMA 31 binds to GPX4 and induces ferroptosis in OVCAR-8 and HT-1080 fibrosarcoma cells.2,3 It also reduces tumor growth in an OVCAR-8 mouse xenograft model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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