An agonist of muscle-type nAChRs
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Succinylcholine (chloride hydrate)

Item No. 32829

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2′-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethyl-ethanaminium, dichloride, dihydrate
CAS Number
6101-15-1
Synonyms
  • Suxamethonium
Molecular Formula
C14H30N2O4 • 2Cl [2H2O]
Formula Weight
397.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C(CCC(OCC[N+](C)(C)C)=O)OCC[N+](C)(C)C.[Cl-].O.O.[Cl-]O=C(CCC(OCC[N+](C)(C)C)=O)OCC[N+](C)(C)C.[Cl-].O.O.[Cl-]
InChi Code
InChI=1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2
InChi Key
FFSBEIRFVXGRPR-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $55

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    25 g

    $103

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    Product Description

    Succinylcholine is an agonist of muscle-type nicotinic acetylcholine receptors (nAChRs).1 It activates the muscle-type α1β1δε subunit-containing nAChR (EC50 = 10.8 µM in X. laevis oocytes expressing the human receptor) then induces desensitization of the receptor. It is selective for the muscle-type nAChR over α3β2, α3β4, α4β2, or α7 subunit-containing neuronal nAChRs (IC50s = >100 µM). Succinylcholine (600 µg) induces neuromuscular block in isolated rat phrenic nerve-diaphragm preparations stimulated via the phrenic nerve.2 Formulations containing succinylcholine have been used as an adjunct to general anesthesia for its muscle relaxant properties.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jonsson, M., Dabrowski, M., Gurley, D.A., et al. Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology 104(4), 724-733 (2006).

    2. Whittaker, R. The neuromuscular blocking action of suxamethonium on the rat diaphragm. J. Pharm. Pharmacol. 14(1), 177-181 (1962).