A 5-HT1A receptor agonist
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S 14506

Item No. 32838

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-benzamide
CAS Number
135722-25-7
Molecular Formula
C24H26FN3O2
Formula Weight
407.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
O=C(C1=CC=C(C=C1)F)NCCN2CCN(CC2)C3=CC=CC4=CC=C(C=C43)OC
InChi Code
InChI=1S/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29)
InChi Key
IFMQODYDAUKKEN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $203

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    Product Description

    S 14506 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A.1,2,3,4 It selectively binds 5-HT1A over 5-HT1B, 5-HT1C, 5-HT2, and 5-HT3 receptors (Kis = 0.98, 281.8, 31.6, 229, and >1,000 nM, respectively) but also binds the dopamine D2 receptor (Ki = 4.57 nM) in radioligand binding assays.1,2 S 14506 stimulates GTPase activity in HEK293 cell membranes expressing 5-HT1A-Gαi1 or 5-HT1A-Gαo1 fusion proteins in a concentration-dependent manner.3 It reduces immobility time in the forced swim test in rats with a minimum effective dose (MED) of 0.01 mg/kg.4 S 14506 (0.0025-0.63 mg/kg) increases punished responding in a pigeon conflict procedure, indicating anxiolytic-like activity.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Colpaert, F.C., Koek, W., Lehmann, J., et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Dev. Res. 26(1), 21-48 (1992).

    2. Protais, P., Chagraoui, A., Arbaoui, J., et al. Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. Eur. J. Pharmacol. 271(1), 167-177 (1994).

    3. Milligan, G., Kellett, E., Dacquet, C., et al. S 14506: Novel receptor coupling at 5-HT1A receptors. Neuropharmacology 40(3), 334-344 (2000).

    4. Schreiber, R., Brocco, M., Gobert, A., et al. The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. Eur. J. Pharmacol. 271(2-3), 537-541 (1994).