A calmodulin inhibitor
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CGS 9343B

Item No. 32844

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one, 2Z-butenedioate
CAS Number
109826-27-9
Synonyms
  • KW-5617
  • Zaldaride Maleate
Molecular Formula
C26H28N4O2 • C4H4O4
Formula Weight
544.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: slightly soluble, warmed
SMILES
CC1(C2=CC=CN2C3=CC=CC=C3CO1)CN4CCC(N5C(NC6=CC=CC=C65)=O)CC4.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C26H28N4O2.C4H4O4/c1-26(24-11-6-14-29(24)22-9-4-2-7-19(22)17-32-26)18-28-15-12-20(13-16-28)30-23-10-5-3-8-21(23)27-25(30)31;5-3(6)1-2-4(7)8/h2-11,14,20H,12-13,15-18H2,1H3,(H,27,31);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
NGODOSILXOFQPH-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $215

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    25 mg

    $437

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    Product Description

    CGS 9343B is a calmodulin inhibitor.1,2,3 It inhibits calmodulin-induced phosphodiesterase (PDE) activity (IC50 = 3.3 µM) but does not inhibit basal PKC activity at 100 µM.2 CGS 9343B (120 µM) inhibits calcium release induced by inositol 1,4,5-trisphosphate (IP3) in 261B rat liver epithelial cells.2 It reduces the incidence of diarrhea without affecting gastrointestinal transit time in a mouse model of secretory diarrhea induced by castor oil when administered at a dose of 3 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Norman, J.A., Ansell, J., Stone, G.A., et al. CGS 9343B, a novel, potent, and selective inhibitor of calmodulin activity. Mol. Pharmacol. 31(5), 535-540 (1987).

    2. Hill, T.D., Campos-Gonzalez, R., Kindmark, H., et al. Inhibition of inositol trisphosphate-stimulated calcium mobilization by calmodulin antagonists in rat liver epithelial cells. The Journal of Biological Chemisty 263(31), 16479-16484 (1988).

    3. Shook, J.E., Burks, T.F., Wasley, J.W., et al. Novel calmodulin antagonist CGS 9343B inhibits secretory diarrhea. J. Pharmacol. Exp. Ther. 251(1), 247-252 (1989).