An inhibitor of Kv7.2
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DMP 543

Item No. 32849

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
CAS Number
160588-45-4
Molecular Formula
C26H18F2N2O
Formula Weight
412.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
O=C1C2=C(C(CC3=CC=NC(F)=C3)(CC4=CC=NC(F)=C4)C5=C1C=CC=C5)C=CC=C2
InChi Code
InChI=1S/C26H18F2N2O/c27-23-13-17(9-11-29-23)15-26(16-18-10-12-30-24(28)14-18)21-7-3-1-5-19(21)25(31)20-6-2-4-8-22(20)26/h1-14H,15-16H2
InChi Key
MUJBUUDUXGDXLW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $169

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    Product Description

    DMP 543 is an inhibitor of the voltage-gated potassium channel Kv7.2 (IC50 = 0.048 µM) and a derivative of linopirdine (Item No. 19547).1,2 It enhances potassium-induced acetylcholine (ACh) release in rat hippocampal slices (EC50 = 0.83 µM).2 DMP 543 (1 mg/kg) increases hippocampal extracellular ACh levels in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Porter, J.D., Vivas, O., Weaver, C.D., et al. An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders. Bioorg. Med. Chem. Lett. 29(23), 126681 (2019).

    2. Zaczek, R., Chorvat, R.J., Saye, J.A., et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: Comparison to linopirdine. J. Pharmacol. Exp. Ther. 285(2), 724-730 (1998).