Host: E. coli • AA: 24-91 • MW: 8 kDa
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CCL5/RANTES (human, recombinant)

Item No. 32858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • C-C Motif Chemokine Ligand 5
  • Regulated Upon Activation, Normally T Expressed and Secreted
  • SIS-δ
  • T Cell-specific Protein P288
  • T Cell-specific Protein RANTES
  • TCP288
Purity
≥95% estimated by SDS-PAGE
Source
Recombinant human CCL5 expressed in E. coli
Amino Acids
24-91
MW
8 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
Host
E. coli
UniProt Accession №
P13501
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    20 µg

    $216

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    100 µg

    $517

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    1 mg

    $3,017

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    Cayman Chemical
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    Product Description

    Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES, is a pro-inflammatory chemokine and member of the CC subfamily of chemokines.1 It is composed of an unstructured N-terminal region, a flexible loop, a 310-helix, three strands of an antiparallel β-sheet, and a single C-terminal α helix.2 It is expressed in T cells, platelets, macrophages, tubular epithelial cells, synovial fibroblasts, and endothelial cells, as well as some tumor cells.1 It functions as a monomer or various oligomers and interacts with the G protein-coupled receptors (GPCRs) chemokine (C-C motif) receptor 1 (CCR1), CCR3, CCR4, CCR5, and GPR75 to activate cell signaling in an oligomerization state-dependent manner. It also interacts with the non-signaling receptors ACKR1, ACKR2, and CCRL2. CCL5 functions as a chemoattractant of immune cells that predominantly express CCR5, such as activated T cells and monocytes, as well as those expressing CCR1 and CCR3, including macrophages and eosinophils, respectively.3 Production of CCL5 is induced in response to viral infections, including HIV, rhinoviruses, respiratory syncytial virus (RSV), coronaviruses, and influenza.4 CCL5 expression positively correlates with disease progression in patients with breast cancer.1 Cayman's CCL5/RANTES (human, recombinant) protein consists of 69 amino acids and has a calculated molecular weight of 8 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Velasco-Velázquez, M., Xolalpa, W., and Pestell, R.G. The potential to target CCL5/CCR5 in breast cancer. Expert Opin. Ther. Targets 18(11), 1265-1275 (2014).

    2. Abayev, M., Rodrigues, J.P.G.L.M., Srivastava, G., et al. The solution structure of monomeric CCL5 in complex with a doubly sulfated N-terminal segment of CCR5. FEBS J. 285(11), 1988-2003 (2018).

    3. Katsounas, A., Schlaak, J.F., and Lempicki, R.A. CCL5: A double-edged sword in host defense against the hepatitis C virus. Int. Rev. Immunol. 30(5-6), 366-378 (2011).

    4. Marques, R.E., Guabiraba, R., Russo, R.C., et al. Targeting CCL5 in inflammation. Expert Opin. Ther. Targets 17(12), 1439-1460 (2013).