An inhibitor of β-catenin/TCF complex signaling
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CCT031374 (hydrobromide)

Item No. 32866

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[1,1′-biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)-ethanone, monohydrobromide
CAS Number
1219184-91-4
Molecular Formula
C23H19N3O • HBr
Formula Weight
434.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(CN1C2=C(N3C1=NCC3)C=CC=C2)C4=CC=C(C5=CC=CC=C5)C=C4.Br
InChi Code
InChI=1S/C23H19N3O.BrH/c27-22(19-12-10-18(11-13-19)17-6-2-1-3-7-17)16-26-21-9-5-4-8-20(21)25-15-14-24-23(25)26;/h1-13H,14-16H2;1H
InChi Key
MPILENOYNNNGKO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $40

    Add

    5 mg

    $136

    Add

    10 mg

    $231

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    CCT031374 is an inhibitor of β-catenin/transcription factor (TCF) complex signaling.1 It inhibits TCF-dependent transcription induced by expression of ∆N-β-catenin, a constitutively active, stabilized form of β-catenin, but not expression of a constitutively active TCF-VP16 fusion protein in reporter assays at 30 µM. CCT031374 (80 µM) induces apoptosis in, and inhibits growth of, HCT116 colon cancer cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ewan, K., Pajak, B., Stubbs, M., et al. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70(14), 5963-5973 (2010).