An agonist of TLR1/2
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CU-T12-9

Item No. 32867

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-4-nitro-2-[4-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl]-benzenamine
CAS Number
1821387-73-8
Molecular Formula
C17H13F3N4O2
Formula Weight
362.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
CNC(C(N1C=C(C2=CC=C(C(F)(F)F)C=C2)N=C1)=C3)=CC=C3[N+]([O-])=O
InChi Code
InChI=1S/C17H13F3N4O2/c1-21-14-7-6-13(24(25)26)8-16(14)23-9-15(22-10-23)11-2-4-12(5-3-11)17(18,19)20/h2-10,21H,1H3
InChi Key
LITXVDAFEYLWQE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $186

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    Cayman Chemical
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    Product Description

    CU-T12-9 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.1 It is selective for TLR1/2 over the TLR2/6 heterodimer in a secreted alkaline phosphatase (SEAP) assay at concentrations up to 10 µg/ml using HEK-Blue cells expressing human TLR2 and endogenously expressing both TLR1 and TLR6 and anti-TLR antibodies. CU-T12-9 (5 µM) induces NF-κB signaling in a reporter assay. It also increases nitric oxide (NO) production in RAW 264.7 cells and primary rat macrophages at 3.6 and 0.4 µM, respectively, and TNF-α production in RAW 264.7 cells (EC50 = 0.06 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, K., Gao, M., Godfroy, J.I., et al. Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists. Sci. Adv. 1(3), e1400139 (2015).