A P2X4 receptor antagonist
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BX-430

Item No. 32868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N′-3-pyridinyl-urea
CAS Number
688309-70-8
Synonyms
  • Blocker of P2X4 Compound 3.0
Molecular Formula
C15H15Br2N3O
Formula Weight
413.1
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
CC(C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1)C
InChi Code
InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)
InChi Key
JFNKIJKRXKPQCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $203

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    Product Description

    BX-430 is a noncompetitive allosteric antagonist of the purinergic P2X4 receptor (IC50s = 0.54 and 1.89 µM for the human and Xenopus receptors, respectively).1 BX-430 is selective for the human P2X4 receptor over the human P2X1, P2X2, P2X5, P2X3, and P2X7 receptors at 5 µM and over mouse and rat P2X4 receptors at 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ase, A.R., Honson, N.S., Zaghdane, H., et al. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol. Pharmacol. 87(4), 606-616 (2015).