A cephalosporin antibiotic
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Pro-drug Form(s)
39538Cefotiam hexetil (hydrochloride)
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Cefotiam (hydrochloride hydrate)

Item No. 32871

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[2-(2-amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, dihydrochloride, hydrate
Synonyms
  • Cephotiam
  • CGP 14221
  • CGP 14221/E
  • CTM
  • SCE 963
Molecular Formula
C18H23N9O4S3 • 2HCl [XH2O]
Formula Weight
598.5
Purity
≥80%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
259 nm
SMILES
OC(C1=C(CS[C@@]2([C@H](NC(CC3=CSC(N)=N3)=O)C(N21)=O)[H])CSC4=NN=NN4CCN(C)C)=O.Cl.Cl.O
InChi Code
InChI=1S/C18H23N9O4S3.2ClH.H2O/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H;1H2/t12-,15-;;;/m1.../s1
InChi Key
KHUCCKUOJMXYKH-BUWDDJPCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

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    Product Description

    Cefotiam is a broad-spectrum cephalosporin antibiotic.1 It inhibits the growth of the Gram-positive bacterium S. aureus (MIC50 = 0.26 µg/ml) and the Gram-negative bacteria P. aeruginosa, E. coli, and H. influenzae (MIC50s = 1, 0.06, and 0.01 µg/ml, respectively). Cefotiam increases survival in mouse models of infection with the 853E and 630E strains of S. aureus (ED50s = 3.5 and 8.3 mg/kg, respectively) and various strains of E. coli (ED50s = 0.5-25 mg/kg).2 Formulations containing cefotiam have previously been used in the treatment of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Limbert, M., Klesel, N., Seeger, K., et al. Cefodizime, an aminothiazolylcephalosporin. I. In vitro activity. J. Antibiot. (Tokyo) 37(8), 892-900 (1984).

    2. Acred, P., Ryan, D.M., Sowa, M.A., et al. The in-vivo antibacterial activity of ceftazidime (Gr 20263)—a comparison with other new β-lactam antibiotics and gentamicin. J. Antimicrob. Chemother. 8(Suppl. B), 247-255 (1981).