An AT2 receptor agonist
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CGP 42112

Item No. 32874

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl-L-isoleucine
CAS Number
127060-75-7
Molecular Formula
C52H69N13O11
Formula Weight
1052.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@H](NC(C2=CN=CC=C2)=O)C(N[C@@H](CCCCNC([C@H](CCCNC(N)=N)NC(OCC3=CC=CC=C3)=O)=O)C(N[C@@H](CC4=CN=CN4)C(N5[C@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CCC5)=O)=O)=O
InChi Code
InChI=1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1
InChi Key
UXGNARZDONUMMK-LRMQDCNJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $142

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    5 mg

    $426

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    10 mg

    $710

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    Product Description

    CGP 42112 is an angiotensin II type 2 (AT2) receptor agonist.1,2 It binds to AT2 receptors (Ki = 0.24 nM) and inhibits cGMP production and tyrosine hydroxylase activity in primary porcine adrenal medullary cells when used at concentrations ranging from 0.001 to 1 µM, effects that can be blocked by the AT2 receptor antagonist PD 123319 (Item No. 16099).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Criscione, L., Thomann, H., Whitebread, S., et al. Binding characteristics and vascular effects of various angiotensin II antagonists. J. Cardiovasc. Pharmacol. 16 (Suppl 4), S56-S59 (1990).

    2. Takekoshi, K., Isobe, K.I., Nanmoku, T., et al. Angiotensin-II subtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured porcine adrenal medullary chromaffin cells. Biochem. Biophys. Res. Commun. 272(2), 544-550 (2000).