A peptide AT2 receptor agonist
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Saralasin (trifluoroacetate salt)

Item No. 32876

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-alanine, trifluoroacetate salt
Synonyms
  • Aralasin
  • 1-Sar-8-Ala-Angiotensin II
Molecular Formula
C42H65N13O10 • XCF3COOH
Formula Weight
912.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@H](NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@@H](C)C(O)=O)=O)CCC3)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C42H65N13O10.C2HF3O2/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65;3-2(4,5)1(6)7/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47);(H,6,7)/t24-,28-,29-,30-,31-,33-,34-;/m0./s1
InChi Key
MSJJUBUOJZCFIK-LYHTUURTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $158

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    25 mg

    $349

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    50 mg

    $609

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    Product Description

    Saralasin is a peptide angiotensin II type 2 (AT2) receptor agonist.1 It binds to AT2 receptors (Ki = 0.38 nM) and induces neurite outgrowth in NG108-15 cells when used at a concentration at 100 nM, an effect that can be inhibited by the AT2 receptor antagonist PD 123310. Saralasin (5 µg/animal, i.c.v.) enhances acquisition of the conditioned avoidance response in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guimond, M.-O., Hallberg, M., Gallo-Payet, N., et al. Saralasin and sarile are AT2 receptor agonists. ACS Med. Chem. Lett. 5(10), 1129-1132 (2014).

    2. Wright, J.W., and Harding, J.W. Brain angiotensin receptor subtypes AT1, AT2, and AT4 and their functions. Regul. Pept. 59(3), 269-295 (1995).