A bacterial metabolite with diverse biological activities
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Benastatin C

Item No. 32894

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,7,9,11-tetrahydroxy-13,13-dimethyl-3-pentyl-benzo[a]naphthacen-8(13H)-one
CAS Number
150151-88-5
Molecular Formula
C29H28O5
Formula Weight
456.5
Purity
≥90%
Formulation
A solid
SMILES
OC(C1=C2C=C3C(C)(C)C4=C5C(O)=CC(O)=C4)=CC(CCCCC)=CC1=CC=C2C(O)=C3C5=O
InChi Code
InChI=1S/C29H28O5/c1-4-5-6-7-15-10-16-8-9-18-19(24(16)22(31)11-15)14-21-26(27(18)33)28(34)25-20(29(21,2)3)12-17(30)13-23(25)32/h8-14,30-33H,4-7H2,1-3H3
InChi Key
QUNHGOCXEGJZAT-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp. MI384-DF12
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $623

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    Product Description

    Benastatin C is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities.1,2 It inhibits glutathione S-transferase (GST; IC50 = 24 µg/ml for the rat liver enzyme).2 Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50 = 10 µg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Z., Schenk, A., and Hertweck, C. Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids. J. Am. Chem. Soc. 129(18), 6022-6030 (2007).

    2. Aoyama, T., Kojima, F., Yamazaki, T., et al. Benastatins C and D, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. Production, isolation, structure determination and biological activities. J. Antibiot. (Tokyo) 46(5), 712-718 (1993).