A bacterial metabolite and an inhibitor of dopamine β-hydroxylase
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Dopastin

Item No. 32896

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-[(2S)-2-(hydroxynitrosoamino)-3-methylbutyl]-2-butenamide
CAS Number
37134-80-8
Synonyms
  • NSC 252927
Molecular Formula
C9H17N3O3
Formula Weight
215.3
Purity
≥90%
Formulation (Request formulation change)
A solid
SMILES
O=C(NC[C@@H](N(N=O)O)C(C)C)/C=C/C
InChi Code
InChI=1S/C9H17N3O3/c1-4-5-9(13)10-6-8(7(2)3)12(15)11-14/h4-5,7-8,15H,6H2,1-3H3,(H,10,13)/b5-4+/t8-/m1/s1
InChi Key
FJUBKTNNXRFHFD-WTSVBCDHSA-N
Origin
Bacterium/Pseudomonas
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $623

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    Product Description

    Dopastin is a bacterial metabolite that has been found in Pseudomonas and an inhibitor of dopamine β-hydroxylase (Ki = 4.7 µM).1,2 In vivo, dopastin (20 mg/kg) reduces mean systolic blood pressure in spontaneously hypertensive rats. Dopastin also inhibits the germination of barley seeds (IC50 = 47 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iinuma, H., Takeuchi, T., Kondo, S., et al. Dopastin, an inhibitor of dopamine β-hydroxylase. J. Antibiot. (Tokyo) 25(8), 497-500 (1972).

    2. Iinuma, H., Matsuzaki, M., Nagatsu, T., et al. Biochemical and biological studies on dopastin, an inhibitor of dopamine β-hydroxylase. Agric. BioI. Chem. 38(11), 2107-2111 (1974).