A monoterpene alkaloid with acaricidal and anticancer activities
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Altemicidin

Item No. 32897

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(aminocarbonyl)-7-[[2-(aminosulfonyl)acetyl]amino]-2,4aR,5,6S,7R,7aS-hexahydro-6-hydroxy-2-methyl-1H-cyclopenta[c]pyridine-7-carboxylic acid
CAS Number
125399-82-8
Synonyms
  • (-)-Altemicidin
Molecular Formula
C13H20N4O7S
Formula Weight
376.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
λmax
294 nm
SMILES
NS(CC(N[C@@]1([C@@]2([H])[C@@](C(C(N)=O)=CN(C2)C)([H])C[C@@H]1O)C(O)=O)=O)(=O)=O
InChi Code
InChI=1S/C13H20N4O7S/c1-17-3-7(11(14)20)6-2-9(18)13(12(21)22,8(6)4-17)16-10(19)5-25(15,23)24/h3,6,8-9,18H,2,4-5H2,1H3,(H2,14,20)(H,16,19)(H,21,22)(H2,15,23,24)/t6-,8+,9-,13+/m0/s1
InChi Key
VZRFZUPFQKSXPV-VPFIQFBESA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $623

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    Product Description

    Altemicidin is a monoterpene alkaloid originally isolated from S. sioyaensis with acaricidal and anticancer activities.1 It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s = 0.84 and 0.82 µg/ml, respectively). It is toxic to mice with an LD50 value of 0.3 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takahashi, A., Kurasawa, S., Ikeda, D., et al. Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties. J. Antibiot. (Tokyo) 42(11), 1556-1561 (1989).