A bacterial metabolite
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Pyridindolol

Item No. 32914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α1R-(hydroxymethyl)-9H-pyrido[3,4-b]indole-1,3-dimethanol
CAS Number
55812-46-9
Synonyms
  • NSC 266530
Molecular Formula
C14H14N2O3
Formula Weight
258.3
Purity
≥90%
Formulation
A crystalline solid
SMILES
OC[C@@H](C1=C2C(C3=CC=CC=C3N2)=CC(CO)=N1)O
InChi Code
InChI=1S/C14H14N2O3/c17-6-8-5-10-9-3-1-2-4-11(9)16-13(10)14(15-8)12(19)7-18/h1-5,12,16-19H,6-7H2/t12-/m0/s1
InChi Key
VAKXHGQDPLEUTH-LBPRGKRZSA-N
Origin
Bacterium/Streptomyces alboverticilliatus MD401-C5
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $868

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    Product Description

    Pyrindolol is a bacterial metabolite that has been found in S. alboverticillatus.1 It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 µg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated from C. perfringens, Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 µg/ml for all).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aoyagi, T., Kumagai, M., Hazato, T., et al. Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetes. J. Antibiot. (Tokyo) 28(7), 555-557 (1975).

    2. Kumagai, M., Aoyagi, T., and Umezawa, H. Inhibitory activity of pyridindolol on β-galactosidase. J. Antibiot. (Tokyo) 29(7), 696-703 (1976).