A PCA-1 inhibitor
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HUHS015

Item No. 32915

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methyl-1-(6-methyl-1H-benzimidazol-2-yl)-4-(phenylmethyl)-1H-pyrazol-5-ol
CAS Number
1453097-13-6
Molecular Formula
C19H18N4O
Formula Weight
318.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/mlEthanol: slightly soluble
λmax
301 nm
SMILES
OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=C(N3)C=C(C)C=C4
InChi Code
InChI=1S/C19H18N4O/c1-12-8-9-16-17(10-12)21-19(20-16)23-18(24)15(13(2)22-23)11-14-6-4-3-5-7-14/h3-10,24H,11H2,1-2H3,(H,20,21)
InChi Key
LFEFEOLVKXXVGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    10 mg

    $75

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    50 mg

    $333

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    100 mg

    $553

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    Cayman Chemical
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    Product Description

    HUHS015 is an inhibitor of prostate cancer antigen-1 (PCA-1; IC50 = 0.67 µM), also known as α-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3).1 It inhibits proliferation of DU145 human prostate cancer cells by 54 and 81% in 2D dish and 3D agar assays, respectively when used at a concentration of 10 µM. HUHS015 (32 mg/kg) reduces tumor growth in a DU145 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakao, S., Mabuchi, M., Shimizu, T., et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg. Med. Chem. Lett. 24(4), 1071-1074 (2014).