A fungal metabolite
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Emeguisin A

Item No. 32929

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-chloro-3,8-dihydroxy-4,9-dimethyl-1,6-bis(1-methyl-1-propenyl)-11H-dibenzo[b,e][1,4]dioxepin-11-one
CAS Number
117032-54-9
Molecular Formula
C23H23ClO5
Formula Weight
414.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C1OC2=C(C(C(C)=CC)=C(C(O)=C2C)Cl)OC3=C1C(C(C)=CC)=CC(O)=C3C
InChi Code
InChI=1S/C23H23ClO5/c1-7-10(3)14-9-15(25)12(5)20-17(14)23(27)29-21-13(6)19(26)18(24)16(11(4)8-2)22(21)28-20/h7-9,25-26H,1-6H3
InChi Key
NNSBJESOIUHEGF-UHFFFAOYSA-N
Origin
Fungus/Emericella sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Emeguisin A is a depsidone fungal metabolite originally isolated from E. unguis.1 It is active against the bacteria S. aureus and methicillin-resistant S. aureus (MRSA; MIC = 0.5 µg/ml for both), the fungus C. neoformans (MIC = 0.5 µg/ml), and the protozoan P. falciparum (IC50 = 2.2 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawahara, N., Nozawa, K., Nakajima, S., et al. Isolation and structures of novel fungal depsidones, emeguisins A, B, and C, from Emericella unguis. J. Chem. Soc. Perkin 1 2611-2614 (1988).

    2. Klaiklay, S., Rukachaisirikul, V., Aungphao, W., et al. Depsidone and phthalide derivatives from the soil-derived fungus Aspergillus unguis PSU-RSPG199. Tetrahedron Lett. 57(39), 4348-4351 (2016).