A bacterial metabolite
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Vanoxonin

Item No. 32931

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-dihydroxybenzoyl)-L-threonyl-N5-acetyl-N5-hydroxy-L-ornithine
CAS Number
86933-99-5
Synonyms
  • Antibiotic MG 245CF2A
Molecular Formula
C18H25N3O9
Formula Weight
427.4
Purity
≥80%
Formulation
A solid
SMILES
CC(N(O)CCC[C@@H](C(O)=O)NC([C@H]([C@H](O)C)NC(C1=C(C(O)=CC=C1)O)=O)=O)=O
InChi Code
InChI=1S/C18H25N3O9/c1-9(22)14(20-16(26)11-5-3-7-13(24)15(11)25)17(27)19-12(18(28)29)6-4-8-21(30)10(2)23/h3,5,7,9,12,14,22,24-25,30H,4,6,8H2,1-2H3,(H,19,27)(H,20,26)(H,28,29)/t9-,12+,14+/m1/s1
InChi Key
KCWDMHXDGAWLOA-LQJRIPTKSA-N
Origin
Bacterium/Saccharopolyspora hirsuta MG245-CF2
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $702

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    Cayman Chemical
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    Product Description

    Vanoxonin is a bacterial metabolite that has been found in S. hirsuta.1 It forms a complex with vanadium, and the complex inhibits thymidylate synthetase with an IC50 value of 0.7 µg/ml. The vanoxonin-vanadium complex is cytotoxic to L1210 leukemia cells (MIC = 25 µg/ml) and increases survival in Ehrlich murine spontaneous adenocarcinoma and L1210 mouse tumor models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanai, F., Sawa, T., Hamada, M., et al. Vanoxonin, a new inhibitor of thymidylate synthetase. J. Antibiot. (Tokyo) 36(6), 656-660 (1983).