A selenium-containing amino acid
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Se-Methylselenocysteine (hydrochloride)

Item No. 32950

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(methylseleno)-L-alanine, monohydrochloride
CAS Number
863394-07-4
Synonyms
  • Methylselenocysteine
  • Se-MeSeCys
  • Se-methyl-L-Selenocysteine
Molecular Formula
C4H9NO2Se • HCl
Formula Weight
218.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[Se]C[C@H](N)C(O)=O.Cl
InChi Code
InChI=1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1
InChi Key
JMPVTFHGWJDSDV-DFWYDOINSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $63

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    50 mg

    $118

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    100 mg

    $195

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    250 mg

    $392

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    Cayman Chemical
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    Product Description

    Se-Methylselenocysteine is a selenium-containing amino acid that has been found in Allium and has antioxidative and anticancer augmenting activities.1,2 Se-Methylselenocysteine (0.01-10 µM) prevents tert-butyl hydroperoxide-induced increases in malondialdehyde (MDA) levels and glutathione reductase and glutathione peroxidase (GPX) activity, as well as decreases in glutathione (GSH) levels, in HepG2 cells.1 It has an additive effect on irinotecan-induced tumor growth reduction in a FaDu mouse xenograft model when administered at a dose of 5 µg/animal per day.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cuello, S., Ramos, S., Mateos, R., et al. Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide. Anal. Bioanal. Chem. 389(7-8), 2167-2178 (2007).

    2. Azrak, R.G., Cao, S., Pendyala, L., et al. Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent. Biochem. Pharmacol. 73(9), 1280-1287 (2007).