An NMDA receptor agonist
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cis-ABCD

Item No. 32966

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cis-1-amino-1,3-cyclobutanedicarboxylic acid
CAS Number
73550-55-7
Synonyms
  • cis-1-Aminocyclobutane-1,3-dicarboxylic Acid
  • CACB
  • cis-2,4-Methanoglutamate
Molecular Formula
C6H9NO4
Formula Weight
159.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
OC([C@]1(C[C@@H](C1)C(O)=O)N)=O
InChi Code
InChI=1S/C6H9NO4/c7-6(5(10)11)1-3(2-6)4(8)9/h3H,1-2,7H2,(H,8,9)(H,10,11)/t3-,6+
InChi Key
GGMYWPBNZXRMME-MYNUVTBMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $92

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    10 mg

    $138

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    25 mg

    $322

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    Product Description

    cis-ABCD is an NMDA receptor agonist.1 It binds to NMDA receptors (Ki = 0.052 µM) and is selective for NMDA over kainate and AMPA receptors in radioligand binding assays (Kis = >300 µM for both). cis-ABCD induces inward currents in Xenopus oocytes expressing rat NMDA receptors (EC50 = 1.26 µM), an effect that can be blocked by the NMDA receptor antagonist D-2-amino-7-phosphonoheptanoate (D-AP7). In vivo, cis-ABCD (30 and 70 nmol/animal) induces contralateral turning in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lanthorn, T.H., Hood, W.F., Watson, G.B., et al. Cis-2,4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist. Eur. J. Pharmacol. 182(3), 397-404 (1990).

    2. Black, M.D., Crossman, A.R., Hayes, A.G., et al. Acute and chronic behavioural sequelae resulting from intrastriatal injection of an NMDA agonist. Pharmacol. Biochem. Behav. 48(2), 441-446 (1994).