A bacterial metabolite with antibacterial and anticancer activities
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4'-Acetyl Chrysomycin B

Item No. 33024

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3S,4S,5S,6S)-4,5-dihydroxy-6-(1-hydroxy-10,12-dimethoxy-6-oxo-8-vinyl-6H-dibenzo[c,h]chromen-4-yl)-2,4-dimethyltetrahydro-2H-pyran-3-yl acetate
Molecular Formula
C30H30O10
Formula Weight
550.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
CC(O[C@H]1[C@@H](C)O[C@@H](C(C2=C3OC(C4=CC(C=C)=CC(OC)=C4C3=CC(OC)=C52)=O)=CC=C5O)[C@H](O)[C@]1(C)O)=O
InChi Code
InChI=1S/C30H30O10/c1-7-15-10-18-22(20(11-15)36-5)17-12-21(37-6)24-19(32)9-8-16(23(24)25(17)40-29(18)34)26-27(33)30(4,35)28(13(2)38-26)39-14(3)31/h7-13,26-28,32-33,35H,1H2,2-6H3/t13-,26+,27+,28+,30+/m1/s1
InChi Key
LTQMETLCTOYANG-RJGDZKQVSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    4'-Acetyl Chrysomycin B is a bacterial metabolite and derivative of chrysomycin B (Item No. 14189) that has been found in Streptomyces and has antibacterial and anticancer activities.1 It is active against strains of B. subtilis, B. cereus, Corynebacterium bovis, and E. faecalis (MICs = 2-64 µg/ml). 4'-Acetyl Chrysomycin B is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 1.7-14 and 260-370 ng/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wada, S.-I., Sawa, R., Iwanami, F., et al. Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and B. J. Antibiot. (Tokyo) 70(11), 1078-1082 (2017).