A carbamate ester with antiprotozoal and antibiotic activities
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Ronidazole

Item No. 33071

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-methyl-5-nitro-1H-imidazole-2-methanol, 2-carbamate
CAS Number
7681-76-7
Synonyms
  • Ridzol
Molecular Formula
C6H8N4O4
Formula Weight
200.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
λmax
301 nm
SMILES
O=C(N)OCC1=NC=C([N+]([O-])=O)N1C
InChi Code
InChI=1S/C6H8N4O4/c1-9-4(3-14-6(7)11)8-2-5(9)10(12)13/h2H,3H2,1H3,(H2,7,11)
InChi Key
PQFRTXSWDXZRRS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $36

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    10 g

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    25 g

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    Cayman Chemical
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    Product Description

    Ronidazole is a carbamate ester with antiprotozoal and antibiotic activities.1 It is active against a panel of T. foetus isolates with minimum lethal concentrations (MLCs) ranging from 0.625 to 1.25 µg/ml. It is also active against C. difficile bacteria (MIC90 = 0.125 µg/ml).2 Ronidazole (50 mg/kg) inhibits infection relapse in a cat model of experimental T. foetus infection.3 It also inhibits T. muris infection in mice when administered at a concentration of 400 mg/L in drinking water.4 Ronidazole (10 mg/kg) increases survival in a mouse model of C. difficile infection.2 Formulations containing ronidazole have been used in the treatment of T. foetus infection in cats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kather, E.J., Marks, S.L., and Kass, P.H. Determination of the in vitro susceptibility of feline Tritrichomonas foetus to 5 antimicrobial agents. J. Vet. Intern. Med. 21(5), 966-970 (2007).

    2. AbdelKhalek, A., and Seleem, M.N. Repurposing the veterinary antiprotozoal drug ronidazole for the treatment of Clostridioides difficile infection. Int. J. Antimicrob. Agents 56(6), 106188 (2020).

    3. Gookin, J.L., Copple, C.N., Papich, M.G., et al. Efficacy of ronidazole for treatment of feline Tritrichomonas foetus infection. J. Vet. Intern. Med. 20(3), 536-543 (2006).

    4. Steiner, J.M., Schwamberger, S., Pantchev, N., et al. Use of ronidazole and limited culling to eliminate Tritrichomonas muris from laboratory mice. J. Am. Assoc. Lab. Anim. Sci. 55(4), 480-483 (2016).