A fungal metabolite
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Isomer(s)
22585Usnic Acid
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Trypacidin

Item No. 33079

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(−)-4,6′-dimethoxy-6-methyl-3,4′-dioxo-spiro[benzofuran-2(3H),1′-[2,5]cyclohexadiene]-2′-carboxylic acid, methyl ester
CAS Number
1900-29-4
Molecular Formula
C18H16O7
Formula Weight
344.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C1C2(C(C(OC)=O)=CC(C=C2OC)=O)OC3=CC(C)=CC(OC)=C13
InChi Code
InChI=1S/C18H16O7/c1-9-5-12(22-2)15-13(6-9)25-18(16(15)20)11(17(21)24-4)7-10(19)8-14(18)23-3/h5-8H,1-4H3
InChi Key
KMZYINVXZDQCKC-UHFFFAOYSA-N
Origin
Fungus/Aspergillus sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $173

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    5 mg

    $516

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    Product Description

    Trypacidin is a fungal metabolite originally isolated from A. fumigatus.1 It is active against B. subtilis and M. bovis (MICs = 12.5 and 1.25 µg/ml, respectively), as well as T. cruzi and T. gondii (MICs = 5-10 and 10-20 µg/ml, respectively).1,2 It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 µM for both).3 Trypacidin increases survival in a mouse model of T. gondii infection when administered in six doses of 12.5 mg/kg each.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balan, J., Ebringer, L., Nemec, P., et al. Antiprotozoal antibiotics. II. Isolation and characterization of trypacidin, a new antibiotic, active against Trypanosoma cruzi and Toxoplasma gondii. J. Antibiot. (Tokyo) 16, 157-160 (1963).

    2. Song, Z., Liu, Y., Gao, J., et al. Antitubercular metabolites from the marine-derived fungus strain Aspergillus fumigatus MF029. Nat. Prod. Res. 1-8 (2019).

    3. Gauthier, T., Wang, X., Dos Santos, J.S., et al. Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One 7(2), e29906 (2012).