A fungal metabolite
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Preterramide C

Item No. 33097

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4,5-trimethoxy-2-[[2-[(3-pyridinylcarbonyl)amino]benzoyl]amino]-benzoic acid, methyl ester
CAS Number
81469-77-4
Molecular Formula
C24H23N3O7
Formula Weight
465.5
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC(OC)=C(C(OC)=C1NC(C2=C(NC(C3=CC=CN=C3)=O)C=CC=C2)=O)OC)OC
InChi Code
InChI=1S/C24H23N3O7/c1-31-18-12-16(24(30)34-4)19(21(33-3)20(18)32-2)27-23(29)15-9-5-6-10-17(15)26-22(28)14-8-7-11-25-13-14/h5-13H,1-4H3,(H,26,28)(H,27,29)
InChi Key
DXZREYMSIRCHNS-UHFFFAOYSA-N
Origin
Fungus/Aspergillus sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 µg

    $196

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    1 mg

    $659

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    Cayman Chemical
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    Product Description

    Preterramide C is a fungal metabolite that has been found in A. terreus.1 It is active against S. aureus (MIC = 52.4 µM) but not E. aerogenes, P. aeruginosa, or C. albicans (MICs = >100 µM for all).2 Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50 value of 0.1 µg/ml.3 It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50 = 5.48 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, F., Bao, J., Zhang, X.-Y., et al. Asperterrestide A, a cytotoxic cyclic tetrapeptide from the marine-derived fungus Aspergillus terreus SCSGAF0162. J. Nat. Prod. 76(6), 1182-1186 (2013).

    2. Wang, Y., Zheng, J., Liu, P., et al. Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium. Mar. Drugs 9(8), 1368-1378 (2011).

    3. Zhou, Y., Mandi, A., Debbab, A., et al. New austalides from the sponge-associated fungus Aspergillus sp. Eur. J. Org. Chem. 30, 6009-6019 (2011).