A prenylated tricyclic polyketide
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Product Categories

Product Type

Biochemicals

Research Area

Immunology & Inflammation
Adaptive Immunity

Neosartoricin

Item No. 33103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3R)-2-(acetyloxy)-3,4-dihydro-3,6,8,9-tetrahydroxy-3-[(3Z)-4-hydroxy-2-oxo-3-penten-1-yl]-10-(3-methyl-2-buten-1-yl)-1(2H)-anthracenone
CAS Number
1421941-29-8
Molecular Formula
C26H28O9
Formula Weight
484.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
OC1=C2C(C[C@](O)([C@@H](C2=O)OC(C)=O)CC(/C=C(O)/C)=O)=C(C3=CC(O)=CC(O)=C31)C/C=C(C)\C
InChi Code
InChI=1S/C26H28O9/c1-12(2)5-6-17-18-8-15(29)9-20(31)21(18)23(32)22-19(17)11-26(34,10-16(30)7-13(3)27)25(24(22)33)35-14(4)28/h5,7-9,25,27,29,31-32,34H,6,10-11H2,1-4H3/b13-7-/t25-,26+/m1/s1
InChi Key
YDWVJROLLAILGE-VAAQKJRKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $250

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    5 mg

    $927

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    Product Description

    Neosartoricin is a prenylated tricyclic polyketide produced in A. fumigatus and N. fischeri overexpressing the N. fischeri polycyclic prenyltransferase (pcPTase) nsc gene cluster.1 It inhibits the proliferation of anti-CD3 and anti-CD28-stimulated mouse spleen T cells (IC50 = 2.99 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chooi, Y.-H., Fang, J., Liu, H., et al. Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Org. Lett. 15(4), 780-783 (2013).