A hexapeptide fragment of eledoisin
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Eledoisin-related Peptide

Item No. 33115

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-L-methioninamide
CAS Number
2990-43-4
Synonyms
  • Eledoisin Hexapeptide
  • Eledoisin RP
  • KFIGLM-NH2
  • Lys-Phe-Ile-Gly-Leu-Met-NH2
Molecular Formula
C34H58N8O6S
Formula Weight
706.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@@H](N)CCCCN)=O)CC1=CC=CC=C1)=O)=O)=O)=O
InChi Code
InChI=1S/C34H58N8O6S/c1-6-22(4)29(42-33(47)27(19-23-12-8-7-9-13-23)41-31(45)24(36)14-10-11-16-35)34(48)38-20-28(43)39-26(18-21(2)3)32(46)40-25(30(37)44)15-17-49-5/h7-9,12-13,21-22,24-27,29H,6,10-11,14-20,35-36H2,1-5H3,(H2,37,44)(H,38,48)(H,39,43)(H,40,46)(H,41,45)(H,42,47)/t22-,24-,25-,26-,27-,29-/m0/s1
InChi Key
UCWISUCKJRPWFZ-HFYXWKFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $297

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    Product Description

    Eledoisin-related peptide is a hexapeptide fragment of eledoisin (Item No. 28810), an undecapeptide tachykinin neuropeptide and neurokinin (NK) receptor agonist.1,2,3 It induces contractions in isolated guinea pig ileum, as well as α-amylase release from rat parotid gland slices, in a concentration-dependent manner.4 Intrathecal administration of eledoisin-related peptide (1.25-10 µg/animal) reduces tail flick latency in the hot plate test.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Evered, M.D., Fitzsimons, J.T., and De Caro, G. Drinking behaviour induced by intracranial injections of eledoisin and substance P in the pigeon. Nature 268(5618), 332-333 (1977).

    2. Severini, C., Improta, G., Falconieri-Erspamer, G., et al. The tachykinin peptide family. Pharmacol. Rev. 54(2), 285-322 (2002).

    3. Erspamer, V., and Anastasi, A. Structure and pharmacological actions of eledoisin, the active endecapeptide of the posterior salivary glands of Eledone. Experientia 18(2), 58-59 (1962).

    4. Gater, P.R., Jordan, C.C., and Owen, D.G. Relative activities of substance P-related peptides in the guinea-pig ileum and rat parotid gland, in vitro. Br. J. Pharmacol. 75(2), 341-351 (1982).

    5. Yasphal, K., Wright, D.M., and Henry, J.L. Substance P reduces tail-flick latency: Implications for chronic pain syndromes. Pain 14(2), 155-167 (1982).