A bacterial metabolite with antiviral activity
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Actiphenol

Item No. 33119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl]-2,6-piperidinedione
CAS Number
526-02-3
Synonyms
  • Actinophenol
  • NSC 58413
Molecular Formula
C15H17NO4
Formula Weight
275.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C1NC(CC(CC(C2=C(O)C(C)=CC(C)=C2)=O)C1)=O
InChi Code
InChI=1S/C15H17NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h3-4,10,20H,5-7H2,1-2H3,(H,16,18,19)
InChi Key
YTLMIHBTPWTPEV-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $222

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    5 mg

    $827

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    Product Description

    Actiphenol is a bacterial metabolite that has been found in Streptomyces and has antiviral activity.1,2 It is active against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 µg/ml, respectively).1 Actiphenol (50 µg/disc) potentiates the antifungal activity of miconazole (Item No. 15420) against C. albicans in a disc assay.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ji, X.-Y., Zhong, Z.-J., Xue, S.-T., et al. Synthesis and antiviral activities of synthetic glutarimide derivatives. Chem. Pharm. Bull. (Tokyo) 58(11), 1436-1441 (2010).

    2. Fukuda, T., Matsumoto, A., Takahashi, Y., et al. Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132. J. Antibiot. (Tokyo) 58(4), 252-259 (2005).