A cyclic tetrapeptide with calcium channel inhibitory activity
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Onychocin B

Item No. 33134

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6S,12R-dibenzyl-3S-((S)-sec-butyl)-9S-isopropyl-1,7-dimethyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetraone
Molecular Formula
C31H42N4O4
Formula Weight
534.7
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C([C@H](C(C)C)NC([C@@H](CC1=CC=CC=C1)N(C)C2=O)=O)N([C@@H](CC3=CC=CC=C3)C(N[C@@]2([H])[C@@H](C)CC)=O)C
InChi Code
InChI=1S/C31H42N4O4/c1-7-21(4)27-31(39)35(6)24(18-22-14-10-8-11-15-22)28(36)32-26(20(2)3)30(38)34(5)25(29(37)33-27)19-23-16-12-9-13-17-23/h8-17,20-21,24-27H,7,18-19H2,1-6H3,(H,32,36)(H,33,37)/t21-,24+,25-,26-,27-/m0/s1
InChi Key
KZGZTOMXQSOTKE-KOMOQGMXSA-N
Origin
Fungi/Aspergillus sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    250 µg

    $186

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    1 mg

    $664

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    Product Description

    Onychocin B is a cyclic tetrapeptide originally isolated from Onychocola sclerotica that has calcium channel inhibitory activity.1 It inhibits the voltage-gated calcium (Cav) channel Cav1.2 with an IC50 value of 7.1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pérez-Victoria, I., Martín, J., González-Menéndez, V., et al. Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica. J. Nat. Prod. 75(6), 1210-1214 (2012).