A neurotensin ligand
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Kinetensin (human) (trifluoroacetate salt)

Item No. 33138

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine, trifluoroacetate salt
Synonyms
  • IARRHPYFL
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu
Molecular Formula
C56H85N17O11 • XCF3COOH
Formula Weight
1172.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 2 mg/ml
SMILES
CC[C@H](C)[C@H](N)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CN=CN1)C(N2[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)CCC2)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C56H85N17O11.C2HF3O2/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3;3-2(4,5)1(6)7/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t32-,33-,38-,39-,40-,41-,42-,43-,44-,45-;/m0./s1
InChi Key
HWZXQUSPWVIRMH-PFYQBJFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Kinetensin is a nonapeptide that has been found in pepsin-treated human plasma.1 It binds to neurotensin receptors in HT-29 cells and mouse brain (Kis = 1,396 and 149.6 nM, respectively, in radioligand binding assays) but does not induce the accumulation of intracellular calcium in HT-29 cells (EC50 = >10,000 nM).2 It induces histamine release in isolated rat peritoneal mast cells with an EC50 value of approximately 10 µM.3 Intradermal administration of kinetensin induces vascular permeability in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mogard, M.H., Kobayashi, R., Chen, C.F., et al. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin-treated human plasma: Homology with human serum albumin, neurotensin and angiotensin. Biochem. Biophys. Res. Commun. 136(3), 983-988 (1986).

    2. Akunne, H.C., Demattos, S.B., Whetzel, S.Z., et al. Agonist properties of a stable hexapeptide analog of neurotensin, NαMeArg-Lys-Pro-Trp-tLeu-Leu (NT1). Biochem. Pharmacol. 49(8), 1147-1154 (1995).

    3. Sydbom, A., Ware, J., and Mogard, M.H. Stimulation of histamine release by the peptide kinetensin. Agents Actions 27(1-2), 68-71 (1989).