A neuropeptide and GAL receptor agonist
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Galanin (human) (acetate)

Item No. 33139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-histidyl-L-alanyl-L-valylglycyl-L-asparaginyl-L-histidyl-L-arginyl-L-seryl-L-phenylalanyl-L-seryl-L-α-aspartyl-L-lysyl-L-asparaginylglycyl-L-leucyl-L-threonyl-L-serine, acetate
Synonyms
  • GAL (human)
  • Galanin (1-30)
Molecular Formula
C139H210N42O43 • XC2H4O2
Formula Weight
3157.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
O=C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@H](C(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(NCC(N4CCC[C@H]4C(N[C@@H](CC5=CNC=N5)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(NCC(N[C@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CO)C(O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)=O)=O)CC(C)C)=O)=O)CN[H].CC(O)=O
InChi Code
InChI=1S/C139H210N42O43.C2H4O2/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224;1-2(3)4/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149);1H3,(H,3,4)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-;/m0./s1
InChi Key
FNXCSWYQOJWUOE-WOKBQIAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Human galanin is a 30-amino acid neuropeptide and galanin (GAL) receptor agonist.1,2,3,4 It inhibits forskolin-induced cAMP production in HEK293E cells expressing recombinant human GAL1 receptors (EC50 = 0.031 nM) and stimulates inositol phosphate accumulation in CHO cells expressing recombinant human GAL2 receptors (EC50 = 12.3 nM).1,2 Human galanin induces contractions in isolated rat longitudinal fundus strips with an EC50 value of 13.8 nM.3 Intrathecal administration of human galanin (3, 10, and 30 nmol/animal) reduces paw licking and flinching in the second, but not first, phase of the formalin test in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fitzgerald, L.W., Patterson, J.P., Conklin, D.S., et al. Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: Agonist character of chimeric galanin peptides. J. Pharmacol. Exp. Ther. 287(2), 448-456 (1998).

    2. Borowsky, B., Walker, M.W., Huang, L.Y., et al. Cloning and characterization of the human galanin GALR2 receptor. Peptides 19(10), 1771-1781 (1998).

    3. Schmidt, W.E., Kratzin, H., Eckart, K., et al. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc. Natl. Acad. Sci. USA 88(24), 11435-11439 (1991).

    4. Hua, X.-Y., Hayes, C.S., Hofer, A., et al. Galanin acts at GalR1 receptors in spinal antinociception: Synergy with morphine and AP-5. J. Pharmacol. Exp. Ther. 308(2), 574-582 (2004).