A 5-HT1A and 5-HT1B receptor agonist
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RU-24969 (succinate)

Item No. 33142

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole, butanedioic acid (2:1)
CAS Number
66611-27-6
Molecular Formula
C14H16N2O • 1/2C4H6O4
Formula Weight
287.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: slightly solubleEthanol: slightly solublePBS (pH 7.2): 1 mg/ml
λmax
223, 264 nm
SMILES
O=C(CCC(O)=O)O.COC1=CC2=C(NC=C2C3=CCNCC3)C=C1.COC4=CC5=C(NC=C5C6=CCNCC6)C=C4
InChi Code
InChI=1S/2C14H16N2O.C4H6O4/c2*1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10;5-3(6)1-2-4(7)8/h2*2-4,8-9,15-16H,5-7H2,1H3;1-2H2,(H,5,6)(H,7,8)
InChi Key
BNYJLRQAWCQJOM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $142

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    25 mg

    $302

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    50 mg

    $554

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    Product Description

    RU-24969 is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.1 It binds to 5-HT1A and 5-HT1B receptors (IC50s = 9.5 and 6.6 nM, respectively) and is selective for these receptors over 5-HT2 receptors in cell-free assays (IC50 = 5,120 nM). RU-24969 inhibits tritium efflux induced by the 5-HT antagonist methiothepin (Item No. 23138) in tritium-preloaded rat frontal cortex slices (pA2 = 6.27). In vivo, RU-24969 (3 mg/kg) potentiates cocaine-induced increases in nucleus accumbens dopamine levels, as well as the reinforcing effects of cocaine self-administration, in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Middlemiss, D.N. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J. Pharm. Pharmacol. 37(6), 434-437 (1985).

    2. Parsons, L.H., Koob, G.F., and Weiss, F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse 32(2), 132-135 (1999).