A TLR4 agonist
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RS 09 (trifluoroacetate salt)

Item No. 33152

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl-L-serine, trifluoroacetate salt
Synonyms
  • Ala-Pro-Pro-His-Ala-Leu-Ser
  • APPHALS
Molecular Formula
C31H49N9O9 • XCF3COOH
Formula Weight
691.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 10 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
OC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC1=CN=CN1)NC([C@H]2N(C([C@H]3N(C([C@@H](N)C)=O)CCC3)=O)CCC2)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C31H49N9O9.C2HF3O2/c1-16(2)11-20(27(44)38-22(14-41)31(48)49)36-25(42)18(4)35-26(43)21(12-19-13-33-15-34-19)37-28(45)23-7-5-9-39(23)30(47)24-8-6-10-40(24)29(46)17(3)32;3-2(4,5)1(6)7/h13,15-18,20-24,41H,5-12,14,32H2,1-4H3,(H,33,34)(H,35,43)(H,36,42)(H,37,45)(H,38,44)(H,48,49);(H,6,7)/t17-,18-,20-,21-,22-,23-,24-;/m0./s1
InChi Key
JEJDMAALCYLRNZ-QVWBAPIKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $87

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    RS 09 is a peptide agonist of toll-like receptor 4 (TLR4).1 It activates NF-κB in a concentration-dependent manner in a secreted alkaline phosphatase (SEAP) assay using TLR4-expressing HEK293 cells and induces NF-κB nuclear translocation in the same cells. It also induces cytokine secretion from RAW 264.7 cells. RS 09 (25 µg/animal) acts as an adjuvant in mice vaccinated with a KLH-conjugated X-15 antigen, with no antibodies produced in mice receiving RS 09 without the antigen.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shanmugam, A., Rajoria, S., George, A.L., et al. Synthetic toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants. PLoS One 7(2), e30839 (2012).