An inhibitor of MAO-B
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C3

Item No. 33166

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-2S-azetidinecarboxamide
CAS Number
2286257-25-6
Molecular Formula
C18H19FN2O2
Formula Weight
314.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/ml
λmax
226 nm
SMILES
NC([C@H](CC1)N1CC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)=O
InChi Code
InChI=1S/C18H19FN2O2/c19-15-3-1-2-14(10-15)12-23-16-6-4-13(5-7-16)11-21-9-8-17(21)18(20)22/h1-7,10,17H,8-9,11-12H2,(H2,20,22)/t17-/m0/s1
InChi Key
ALMGCZWDJHPQIA-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $218

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    10 mg

    $395

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    Product Description

    C3 is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 0.021 µM).1 It is selective for MAO-B over MAO-A (IC50 = 26.8 µM). C3 (0.1, 1, and 3 mg/kg) prevents MPTP-induced decreases in brain dopamine levels in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jin, C.-F., Wang, Z.-Z., Chen, K.-Z., et al. Computational fragment-based design facilitates discovery of potent and selective monoamine oxidase-B (MAO-B) inhibitor. J. Med. Chem. 63(23), 15021-15036 (2020).