An IDO1 inhibitor
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LY3381916

Item No. 33178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1R)-1-[2,3-dihydro-1-[(tetrahydro-2H-pyran-4-yl)carbonyl]-1H-indol-5-yl]ethyl]-4-fluoro-benzamide
CAS Number
2166616-75-5
Synonyms
  • IDO1-IN-5
Molecular Formula
C23H25FN2O3
Formula Weight
396.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
260 nm
SMILES
O=C(C1CCOCC1)N2C3=CC=C([C@@H](C)NC(C4=CC=C(C=C4)F)=O)C=C3CC2
InChi Code
InChI=1S/C23H25FN2O3/c1-15(25-22(27)16-2-5-20(24)6-3-16)18-4-7-21-19(14-18)8-11-26(21)23(28)17-9-12-29-13-10-17/h2-7,14-15,17H,8-13H2,1H3,(H,25,27)/t15-/m1/s1
InChi Key
NUBWFWVVKLRSHS-OAHLLOKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $178

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    10 mg

    $312

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    25 mg

    $680

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    Product Description

    LY3381916 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1).1 It binds to apo-IDO1, which lacks heme, but does not inhibit mature heme-bound IDO1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dorsey, F.C., Benhadji, K.A., Sams, L.L., et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Res. 78(13 Supplement), 5245 (2018).