A triterpenoid with diverse biological activities
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Pachymic Acid

Item No. 33180

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-(acetyloxy)-16α-hydroxy-24-methylene-lanost-8-en-21-oic acid
CAS Number
29070-92-6
Synonyms
  • 3-O-Acetyltumulosic Acid
  • NSC 244427
Molecular Formula
C33H52O5
Formula Weight
528.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Soluble
SMILES
C[C@]12[C@@]([C@]([C@@H](CCC(C(C)C)=C)C(O)=O)([H])[C@@H](C1)O)(CCC3=C2CC[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)OC(C)=O)C)C
InChi Code
InChI=1S/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1
InChi Key
VDYCLYGKCGVBHN-DRCQUEPLSA-N
Origin
Fungus/Poria cocos
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

    $213

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    25 mg

    $466

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    Product Description

    Pachymic acid is a triterpenoid that has been found in P. cocos and has diverse biological activities.1,2,3,4 It inhibits hexokinase 2 (HK2; IC50 = 5.01 µM), as well as reduces glucose uptake and lactate production in SK-BR-3 breast cancer cells.1 Pachymic acid inhibits IL-1β-induced cytosolic phospholipase A2 (cPLA2) activation and prostaglandin E2 (PGE2; Item No. 14010) production in, as well as inhibits the proliferation of, A549 lung cancer cells.2 It decreases tumor growth in an NCI H23 lung cancer mouse xenograft model when administered at doses of 30 and 60 mg/kg.3 Pachymic acid (10 and 20 mg/kg) prevents increases in serum urea and creatinine levels in a mouse model of renal ischemia-reperfusion injury.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miao, G., Han, J., Zhang, J., et al. Targeting pyruvate kinase M2 and hexokinase II, pachymic acid impairs glucose metabolism and induces mitochondrial apoptosis. Biol. Pharm. Bull. 42(1), 123-129 (2019).

    2. Ling, H., Jia, X., Zhang, Y., et al. Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. Mol. Carcinog. 49(3), 271-282 (2010).

    3. Ma, J., Liu, J., Lu, C., et al. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells. Cancer Cell Int. 15, 78 (2015).

    4. Jiang, G.-P., Liao, Y.-J., Huang, L.-L., et al. Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury. Mol. Med. Rep. 23(1), 1 (2021).