A glucocorticoid
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Diflucortolone 21-valerate

Item No. 33203

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6α,9-difluoro-11β-hydroxy-16α-methyl-21-[(1-oxopentyl)oxy]-pregna-1,4-diene-3,20-dione
CAS Number
59198-70-8
Molecular Formula
C27H36F2O5
Formula Weight
478.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 10 mg/ml
λmax
237 nm
SMILES
F[C@@]12[C@](C[C@@H](C([C@@]2(C=C3)C)=CC3=O)F)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@H]([C@@H](C4)C)C(COC(CCCC)=O)=O)C
InChi Code
InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1
InChi Key
HHJIUUAMYGBVSD-YTFFSALGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    10 mg

    $36

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    50 mg

    $153

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    100 mg

    $288

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    Product Description

    Diflucortolone 21-valerate is a glucocorticoid.1 It has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED50 = 9.7 µg/ml).2 Diflucortolone 21-valerate (0.1%) also induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration and increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization.3,1 Formulations containing diflucortolone 21-valerate have been used in the treatment of inflammatory or allergic skin conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Igawa, K., Katayama, I., Minatohara, K., et al. Topical glucocorticoid augments both allergic and non-allergic cutaneous reactions in mice when applied at the afferent stage of contact sensitivity. Allergol. Int. 46(1), 33-41 (1997).

    2. Yamada, K., Hattori, S., Hakoda, T., et al. A fundamental study on a bioassay for the antiphlogistic effect of topically applied antiinflammatory agents. Nihon Yakurigaku Zasshi 75(8), 789-798 (1979).

    3. Kimura, T., and Doi, K. Dorsal skin reactions of hairless dogs to topical treatment with corticosteroids. Toxicol. Pathol. 27(5), 528-535 (1999).