An Eg5 inhibitor
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BRD9876

Item No. 33217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(1,1-dimethylethyl)-2,3-naphthalenedicarbonitrile
CAS Number
32703-82-5
Molecular Formula
C16H14N2
Formula Weight
234.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlDMF: 1 mg/mlDMF:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
252 nm
SMILES
N#CC1=CC2=CC=C(C(C)(C)C)C=C2C=C1C#N
InChi Code
InChI=1S/C16H14N2/c1-16(2,3)15-5-4-11-6-13(9-17)14(10-18)7-12(11)8-15/h4-8H,1-3H3
InChi Key
MKILROQBJOOZKC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $79

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    5 g

    $365

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    Cayman Chemical
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    Product Description

    BRD9876 is an inhibitor of the kinesin spindle protein Eg5.1 It arrests Eg5-mediated microtubule gliding, as well as inhibits Eg5 ATPase activity in the presence of microtubules, in cell-free assays. BRD9876 is cytotoxic to MM.1S stroma-independent multiple myeloma cells (IC50 = 2.2 µM). It induces cell cycle arrest at the G2/M phase in MM.1S cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chattopadhyay, S., Stewart, A.L., Mukherjee, S., et al. Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitors. Cell Rep. 10(5), 755-770 (2015).