An inhibitor of DPP-4
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Gosogliptin

Item No. 33220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3,3-difluoro-1-pyrrolidinyl)[(2S,4S)-4-[4-(2-pyrimidinyl)-1-piperazinyl]-2-pyrrolidinyl]-methanone
CAS Number
869490-23-3
Synonyms
  • PF 734200
Molecular Formula
C17H24F2N6O
Formula Weight
366.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
[H][C@@]1(N2CCN(C3=NC=CC=N3)CC2)CN[C@H](C(N4CC(F)(F)CC4)=O)C1
InChi Code
InChI=1S/C17H24F2N6O/c18-17(19)2-5-25(12-17)15(26)14-10-13(11-22-14)23-6-8-24(9-7-23)16-20-3-1-4-21-16/h1,3-4,13-14,22H,2,5-12H2/t13-,14-/m0/s1
InChi Key
QWEWGXUTRTXFRF-KBPBESRZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $623

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    Product Description

    Gosogliptin is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 0.013 µM).1 It is selective for DPP-4 over DPP-2, -3, -8, and -9 (IC50s = 3.3, >30, 7, and 5.98 µM, respectively), the serine proteases APP, FAP, and POP (IC50s = >30, 10.3, and >30 µM, respectively), and a panel of enzymes, receptors, and ion channels (IC50s = >10 µM for all).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ammirati, M.J., Andrews, K.M., Boyer, D.D., et al. (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor. Bioorg. Med. Chem. Lett. 19(7), 1991-1995 (2009).