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AZD 3514

Item No. 33222

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[4-[2-[4-[1-[7,8-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]-4-piperidinyl]phenoxy]ethyl]-1-piperazinyl]-ethanone
CAS Number
1240299-33-5
Molecular Formula
C25H32F3N7O2
Formula Weight
519.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
222, 272 nm
SMILES
O=C(C)N1CCN(CC1)CCOC2=CC=C(C3CCN(CC3)C4=NN5C(CC4)=NN=C5C(F)(F)F)C=C2
InChi Code
InChI=1S/C25H32F3N7O2/c1-18(36)33-14-12-32(13-15-33)16-17-37-21-4-2-19(3-5-21)20-8-10-34(11-9-20)23-7-6-22-29-30-24(25(26,27)28)35(22)31-23/h2-5,20H,6-17H2,1H3
InChi Key
JMEYDSHPKCSIJC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    AZD 3514 is a selective androgen receptor downregulator (SARD).1 It inhibits AR nuclear translocation in LNCaP human prostate cancer cells with an IC50 value of 1.78 µM. AZD 3514 (10 µM) inhibits dihydrotestosterone-induced proliferation of LNCaP and LAPC4 prostate cancer cells.2 It reduces testosterone proprionate-induced increases in seminal vesicle weight in castrated rats. AZD 3514 (50 mg/kg) decreases tumor growth of Dunning R3327H prostate tumor implants in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bradbury, R.H., Acton, D.G., Broadbent, N.L., et al. Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer. Bioorg. Med. Chem. Lett. 23(7), 1945-1948 (2013).

    2. Loddick, S.A., Ross, S.J., Thomason, A.G., et al. AZD3514: A small molecule that modulates androgen receptor signaling and function in vitro and in vivo. Mol. Cancer Ther. 12(9), 1715-1727 (2013).