An Ito current activator
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NS 5806

Item No. 33226

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-urea
CAS Number
426834-69-7
Molecular Formula
C16H8Br2F6N6O
Formula Weight
574.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/mlEthanol: 25 mg/ml
λmax
245 nm
SMILES
O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1Br)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3
InChi Code
InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)
InChi Key
UZWJWROOLOOCPQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $293

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    25 mg

    $583

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    Product Description

    NS 5806 is an activator of the calcium-independent transient outward potassium current (Ito).1 It increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a manner dependent on potassium channel interaction protein 2 (KChIP2), in CHO-K1 cells expressing human Kv4.3. NS 5806 increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM).2 It reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog heart in a model of heart failure.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lundby, A., Jespersen, T., Schmitt, N., et al. Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2. Br. J. Pharmacol. 160(8), 2028-2044 (2010).

    2. Cheng, H., Cannell, M.B., and Hancox, J.C. Differential responses of rabbit ventricular and atrial transient outward current Ito to the Ito modulator NS5806. Physiol. Rep. 5(5), e13172 (2017).

    3. Cordeiro, J.M., Calloe, K., Moise, N.S., et al. Physiological consequences of transient outward K+ current activation during heart failure in the canine left ventricle. J. Mol. Cell. Cardiol. 52(6), 1291-1298 (2012).