A triterpenoid sapogenin with diverse biological activities
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Isomer(s)
2505220(R)-Protopanaxadiol
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Panaxadiol

Item No. 33233

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20R,25-epoxy-dammarane-3β,12β-diol
CAS Number
19666-76-3
Synonyms
  • NSC 308879
  • 20(R)-Panaxadiol
Molecular Formula
C30H52O3
Formula Weight
460.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlEthanol: 0.25 mg/ml
SMILES
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)O)([H])[C@]([C@@]5(OC(C)(CCC5)C)C)([H])CC3)C
InChi Code
InChI=1S/C30H52O3/c1-25(2)13-9-14-30(8,33-25)19-10-16-29(7)24(19)20(31)18-22-27(5)15-12-23(32)26(3,4)21(27)11-17-28(22,29)6/h19-24,31-32H,9-18H2,1-8H3/t19-,20+,21-,22+,23-,24-,27-,28+,29+,30+/m0/s1
InChi Key
PVLHOJXLNBFHDX-XHJPDDKBSA-N
Origin
Plant/Panax ginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $204

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    25 mg

    $388

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    50 mg

    $655

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    Product Description

    Panaxadiol is a triterpenoid sapogenin that has been found in P. ginseng and has diverse biological activities.1,2,3,4 It inhibits the growth of HepG2 human hepatoma, A549 lung, MCF-7 breast, and HCT116 colon cancer cells (IC50s = 63.20, 40.88, 61.96, and 92.53 µM, respectively).1 Panaxadiol (30 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model.2 It inhibits hepatitis B virus (HBV) DNA replication in HepG 2.2.15 cells with an IC50 value of 148.15 µM.3 Panaxadiol (50 mg/kg) also decreases the escape latency in the Morris water maze (MWM) in an APP/PS1 mouse model of Alzheimer's disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiao, S., Lin, Z., Wang, X., et al. Synthesis and cytotoxicity evaluation of panaxadiol derivatives. Chem. Biodivers. 17(1), e1900516 (2020).

    2. Wang, Z., Li, M.Y., Zhang, Z.H., et al. Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells. Pharmacol. Res. 155, 104727 (2020).

    3. Chen, H., Wang, L.-J., Ma, Y.-B., et al. Panaxadiol and panaxatriol derivatives as anti-hepatitis B virus inhibitors. Nat. Prod. Bioprospect. 4(3), 163-174 (2014).

    4. Liang, X., Yao, Y., Lin, Y., et al. Panaxadiol inhibits synaptic dysfunction in Alzheimer’s disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells. Life Sci. 221, 35-46 (2019).