An RPE65 inhibitor
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ACU 4429 (hydrochloride)

Item No. 33242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αR)-α-(2-aminoethyl)-3-(cyclohexylmethoxy)-benzenemethanol, monohydrochloride
CAS Number
1141934-97-5
Molecular Formula
C16H25NO2 • HCl
Formula Weight
299.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
222 nm
SMILES
NCC[C@H](C1=CC(OCC2CCCCC2)=CC=C1)O.Cl
InChi Code
InChI=1S/C16H25NO2.ClH/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13;/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2;1H/t16-;/m1./s1
InChi Key
BPZWRYOUJMDQSY-PKLMIRHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $90

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    5 mg

    $219

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    10 mg

    $392

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    25 mg

    $869

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    Product Description

    ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65; IC50 = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Item No. 33207) in the visual cycle.1 It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED50 = 0.21mg/kg) and reversibly decreases the regeneration of 11-cis retinal oxime in the same model (ED50 = 0.18 mg/kg). ACU 4429 also prevents light-induced photoreceptor cell loss in dark-adapted albino mice. It reduces lipofuscin autofluorescence and decreases the level of retinoid toxin (A2E) in the RPE in an Abca4-/- mouse model of Stargardt disease (ED50 = 0.47 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bavik, C., Henry, S.H., Zhang, Y., et al. Visual cycle modulation as an approach toward preservation of retinal integrity. PLoS One 10(5), e0124940 (2015).