A sympathomimetic amine
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Etilefrine (hydrochloride)

Item No. 33249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(ethylamino)methyl]-3-hydroxy-benzenemethanol, monohydrochloride
CAS Number
943-17-9
Synonyms
  • Circupon
  • Ethylephrine
  • Ethylphenylephrine
Molecular Formula
C10H15NO2 • HCl
Formula Weight
217.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
217 nm
SMILES
OC1=CC=CC(C(CNCC)O)=C1.Cl
InChi Code
InChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H
InChi Key
KTNROWWHOBZQGK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $49

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    500 mg

    $93

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    1 g

    $171

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    Product Description

    Etilefrine is a sympathomimetic amine.1 It induces vasoconstriction in isolated perfused rat tail artery segments in a concentration-dependent manner. Etilefrine (45 µg/kg, i.v.) inhibits anesthesia-induced decreases in mean arterial pressure and cardiac output in dogs.2 Formulations containing etilefrine have been used in the treatment of orthostatic hypotension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frost, B.R., Frewin, D.B., and Gerke, D.C. The effects of etilefrine on blood vessels in the rat tail. J. Pharm. Pharmacol. 29(5), 272-275 (1977).

    2. Tarnow, J., Brückner, J.B., Eberlein, H.J., et al. Haemodynamic responses to ethylphenylephrine (Effortil) during halothane-induced myocardial depression in the dog. Acta Anaesthesiol. Scand. 17(3), 184-189 (1973).